Provide regular watering during its establishment phase, ensuring the soil remains consistently moist but not waterlogged. Once mature, Akebia trifoliata exhibits good drought tolerance, requiring less frequent irrigation, especially in cooler climates or during periods of natural rainfall.

Prune Akebia trifoliata in late winter or early spring, before new growth emerges, to control its vigorous size and shape. Remove any dead, damaged, or crossing branches to maintain plant health and air circulation. Hard pruning can be beneficial for rejuvenating older, overgrown vines. Light trimming during summer can help manage rampant growth and keep the vine tidy.

Easily propagated by semi-hardwood cuttings taken in summer, rooted in a moist, well-drained medium with rooting hormone. Layering is also a simple and effective method, where a stem is buried in soil to root while still attached to the parent plant.

Not typically grown in pots long-term due to its vigorous vining habit. If grown in a container temporarily, repot annually into a larger pot with fresh potting mix to accommodate its rapid growth. Ensure excellent drainage to prevent root rot.