Nutmeg trees require consistent moisture, especially during dry periods. Water deeply when the top few centimeters of soil feel dry, but ensure excellent drainage to prevent root rot. Young trees need more frequent watering. Reduce slightly in cooler, less active periods, though it is an evergreen species.

Prune nutmeg trees primarily to maintain a desirable shape, remove any dead, diseased, or damaged branches, and improve air circulation within the canopy. Light pruning can also encourage branching, potentially leading to better fruit production. The best time for pruning is usually after the main harvest period. Avoid heavy pruning, which can stress the tree and reduce yields. Regularly remove any suckers that may emerge from the base of the trunk to direct energy to the main plant.

Myristica fragrans is primarily propagated by fresh seeds, which should be sown quickly as their viability decreases rapidly. Germination can take several weeks to months. Air layering and grafting are also possible methods for clonal propagation, ensuring desired characteristics of the parent plant.

Young nutmeg trees grown in pots will need repotting every 1-2 years into a larger container with fresh, well-draining potting mix. Once mature, they are best grown in the ground in suitable tropical climates. Repotting should be done carefully to minimize root disturbance to the plant.