Young Multiflora Rose plants benefit from regular watering to establish a strong root system, especially during dry periods. Once established, this species is remarkably drought-tolerant and typically requires minimal supplemental irrigation, relying mostly on natural rainfall. Overwatering should be avoided to prevent root issues, as it prefers well-drained conditions.

Pruning is often necessary to manage the vigorous growth of Multiflora Rose, especially where it is invasive. For control, cut stems back to the ground. For ornamental use, prune in late winter or early spring to remove dead, damaged, or crossing branches, and to maintain desired shape and size. Regular pruning can also encourage more prolific flowering.

Multiflora Rose readily propagates from seeds, which are widely dispersed by birds consuming the hips. It can also spread vegetatively through layering, where arching stems touch the ground and root, forming new plants. Stem cuttings can be taken, though success rates vary. Due to its invasive nature, intentional propagation is generally discouraged.

Multiflora Rose is typically grown outdoors in the ground and is not suitable for container cultivation or repotting. Its extensive root system and large, sprawling habit make it impractical for pots. If a very young plant is temporarily in a container, it should be transplanted to its permanent outdoor location as soon as possible to allow for proper development.