Prosopis juliflora is highly drought-tolerant once established. Water deeply but infrequently, allowing the soil to dry out completely between waterings. Overwatering can lead to root rot.

Young plants require more consistent moisture until their root systems are developed.

Pruning is typically done to shape the tree, remove dead or crossing branches, or to manage its size. It tolerates heavy pruning and can be trained as a tree or large shrub.

Prune in late winter or early spring before new growth begins to minimize stress and sap loss.

Prosopis juliflora can be propagated by seeds, which often require scarification or hot water treatment to break dormancy. It can also be propagated by cuttings, though success rates can vary.

Grafting is another method for establishing specific cultivars.

Repotting is rarely necessary for established Prosopis juliflora as it prefers to be root-bound and thrives in well-drained conditions. If a container-grown plant becomes severely root-bound and shows signs of distress, repot into a slightly larger container with excellent drainage in spring.