Water sparingly, allowing the soil to dry out completely between waterings. Overwatering is the most common cause of rot. Reduce watering significantly during the dormant winter period.

Ensure good drainage to prevent waterlogged roots.

Pruning is generally not required for Euphorbia obesa. If any parts become damaged or diseased, they can be carefully removed with a sterile knife. Focus on maintaining the plant's natural spherical shape.

Propagation is primarily done through seeds. Sow seeds in a well-draining cactus mix. Cuttings can be taken, but they are prone to rot and require careful handling and drying before planting.

Repot every 2-3 years or when the plant becomes root-bound, preferably in spring. Use a well-draining cactus or succulent potting mix. Choose a pot slightly larger than the current one with drainage holes.