Penstemon fruticosus prefers well-drained soil and is moderately drought-tolerant once established. Water deeply but infrequently, allowing the soil to dry out between waterings.

Reduce watering significantly in cooler months to prevent root rot, especially in winter.

Prune in late winter or early spring before new growth emerges. Remove any dead, damaged, or crossing branches. Lightly shape the plant to maintain a tidy appearance and encourage denser flowering.

Avoid heavy pruning as it can stress the plant.

Propagate Penstemon fruticosus from seed sown in autumn or early spring, requiring a period of cold stratification. Cuttings taken in late spring or early summer can also be rooted in moist, well-draining medium.

Success rates are moderate.

Repot young plants as needed, typically every 1-2 years, when they become root-bound. Use a well-draining potting mix. Established plants in the ground rarely need repotting and generally dislike being disturbed.