Allow the soil to dry out completely between waterings. Euphorbia lophogona is drought-tolerant and prone to root rot if overwatered.

Water thoroughly when the top few inches of soil are dry, ensuring good drainage to prevent waterlogging. Reduce watering significantly during winter dormancy.

Prune to maintain shape, remove dead or damaged stems, or control size. Use clean, sharp tools. Wear gloves as the sap can be irritating. Pruning is best done in spring before new growth begins.

Cut stems back to a desired length or remove unwanted branches at their base.

Propagate by stem cuttings or seeds. For stem cuttings, take a 10-15 cm piece, allow the sap to dry for a day or two, then plant in well-draining soil. Seeds can be sown in spring in a well-draining mix.

Cuttings are generally easier and faster for home propagation.

Repot every 2-3 years, or when the plant becomes root-bound. Use a well-draining cactus or succulent mix. Choose a pot that is only slightly larger than the current one. Repot in spring before the active growing season.

Handle with care due to the sharp spines and sap.