Water Leonurus quinquelobatus regularly during the growing season, allowing the soil to dry out slightly between waterings. Reduce watering in autumn and winter, especially if grown in cooler conditions.

Ensure good drainage to prevent root rot, as this plant prefers moderately moist soil.

Prune Leonurus quinquelobatus in late autumn or early spring to remove dead or damaged stems and to shape the plant. Deadheading spent flowers can encourage a second bloom.

Hard pruning can rejuvenate older plants and promote bushier growth.

Propagate Leonurus quinquelobatus by seed sown in spring, either directly outdoors or in a cold frame. It can also be propagated by division of established clumps in early spring, separating the root ball into sections with healthy shoots.

Repotting is generally not necessary for established Leonurus quinquelobatus plants as they are quite tolerant. If growing in containers, repot every 2-3 years in spring into a slightly larger pot with fresh, well-draining potting mix to refresh the soil.