Water thoroughly when the potting medium is completely dry. Avoid overwatering, as this can lead to root rot. Reduce watering significantly during winter dormancy.

Ensure good drainage to prevent waterlogged soil, which is detrimental to Echinopsis ayopayana.

Pruning is generally not necessary for Echinopsis ayopayana unless removing damaged or diseased parts. If offsets need to be separated, they can be carefully removed with a clean knife.

Ensure cuts are allowed to callus over before repotting.

Propagate primarily through offsets (pups) that naturally form around the base of the parent plant. Gently detach these offsets with a clean blade, allow the cut surface to air dry and callus for a few days, then pot them in a well-draining cactus mix.

Repot every 2-3 years or when the plant outgrows its container, preferably in spring. Use a gritty, fast-draining cactus mix. Choose a pot that is only slightly larger than the current one.

Handle with care to avoid spines.