Water thoroughly when the soil is completely dry, typically every 2-3 weeks in summer and much less frequently in winter. Overwatering is a primary cause of root rot.

Allow the soil to dry out completely between waterings to mimic its arid native habitat.

Prune to maintain shape or remove damaged/dead stems. Use clean, sharp tools. Euphorbia nubica can be pruned back significantly if it becomes leggy.

The sap is a skin irritant, so wear gloves and eye protection when pruning.

Propagate from stem cuttings in spring or summer. Allow cuttings to callus for a few days before planting in well-draining soil. Water sparingly until roots form. This method is highly successful for this species.

Repot every 2-3 years or when the plant becomes root-bound. Use a gritty, well-draining potting mix. Choose a pot that is only slightly larger than the previous one. Repot in spring, before active growth begins.