Water Guilandina culebrae moderately when the top 2-3 cm of soil feels dry. Avoid waterlogged conditions, as this can lead to root rot. Reduce watering significantly during the cooler, dormant winter months.

Ensure good drainage to prevent excessive moisture buildup.

Prune Guilandina culebrae lightly to maintain its shape and remove any dead or damaged branches. This can be done in late winter or early spring before new growth begins. Avoid heavy pruning, as it may hinder flowering.

Propagation is typically done through seeds, which may require scarification or stratification to improve germination rates. Cuttings can also be attempted, but success may vary.

Sow seeds or plant cuttings in well-draining soil mix.

Repot Guilandina culebrae every 2-3 years in spring, or when rootbound. Choose a pot that is slightly larger than the current one, ensuring it has drainage holes.

Use a well-draining potting mix, such as a cactus or succulent blend.