Water regularly during establishment, especially in dry periods. Once established, Lopsided Indiangrass is highly drought-tolerant and prefers well-drained soil.

Allow the soil to dry out between waterings to prevent root rot. Overwatering can lead to fungal issues.

Prune back the old growth in late winter or early spring before new growth emerges. This helps to tidy the plant and encourage vigorous new shoots.

Remove any dead or damaged foliage at any time of year to maintain plant health and appearance.

Propagation is typically done through seed or division. Sow seeds in spring or fall. Division of established clumps can be performed in early spring.

Ensure new divisions or seedlings are kept consistently moist until established.

Repotting is rarely necessary for Sorghastrum secundum as it is a perennial grass and typically grown in the ground. If grown in a container, repot only when the plant becomes root-bound, usually every 2-3 years, into a slightly larger pot with fresh, well-draining soil.