Miner's Lettuce prefers consistently moist soil throughout its active growing season, from late winter through spring. Water deeply when the top few centimeters of soil begin to feel dry to the touch, but ensure good drainage to prevent waterlogging, which can lead to root rot. Reduce watering as temperatures rise and the plant naturally senesces in early summer.

Minimal pruning is required for Miner's Lettuce. Regular harvesting of the outer leaves for culinary use will encourage the plant to produce more foliage and can extend the harvest period. If you wish to prevent prolific self-seeding, you can remove the spent flower stalks before they set seed. Otherwise, allow them to remain for naturalization.

Miner's Lettuce is most commonly propagated by seed. Sow seeds directly outdoors in late summer or early autumn for a winter and spring harvest. Seeds require cool temperatures for germination, often benefiting from a period of cold stratification. The plant readily self-seeds, establishing dense patches in suitable conditions, making it an excellent choice for naturalized areas.

Repotting is not typically applicable for Miner's Lettuce as it is an annual or short-lived biennial grown from seed. If cultivating in containers, sow seeds directly into the final pot. Choose a pot that is wide rather than deep to accommodate its spreading, groundcover habit, and ensure it has adequate drainage holes to prevent water accumulation.