Water thoroughly when the soil is completely dry. Pachypodium ambongense is drought-tolerant and prone to root rot if overwatered. Reduce watering significantly during the dormant winter months to prevent issues.

Ensure good drainage to avoid waterlogged conditions.

Pruning is generally not necessary unless removing dead, damaged, or crossing branches. If shaping is desired, prune in spring before new growth begins. Use clean, sharp tools.

Be cautious of the sharp spines and the milky sap.

Propagation is typically done from seeds or cuttings. Seeds require warmth and bright light to germinate.

Cuttings should be taken from healthy stems in spring or summer, allowed to callus for several days, and then planted in well-draining soil.

Repot Pachypodium ambongense every 2-3 years in spring, or when the plant becomes root-bound. Use a well-draining cactus or succulent potting mix. Choose a pot that is only slightly larger than the current one.

Handle with care due to spines.