Petty Spurge is an adaptable annual that prefers consistently moist, well-drained soil but can tolerate periods of drought once established. For optimal growth, especially in cultivated areas where it might be tolerated, water moderately to keep the soil from drying out completely. Avoid overwatering, which can lead to waterlogged conditions, as this plant is not accustomed to standing water. Its resilience means it often thrives with natural rainfall.

Pruning, in the traditional sense, is not applicable for Petty Spurge as it is an annual weed. However, managing its growth is crucial for control. The most effective 'pruning' involves removing or pulling plants entirely before they have a chance to set seed. This prevents the prolific dispersal of seeds and helps reduce future infestations. Regular removal throughout its growing season is key to minimizing its spread in gardens and cultivated areas.

Petty Spurge primarily propagates by seed. Each plant can produce thousands of seeds, which remain viable in the soil for several years. It can also self-seed prolifically, making it a persistent weed. There is no common horticultural propagation method for this plant.

Repotting is not applicable for Petty Spurge as it is an annual weed typically found in gardens or disturbed ground. It completes its life cycle within one growing season and is not cultivated as a potted plant that would require repotting.