Water moderately when the top 2-3 cm of soil feels dry. Buffalobur Nightshade prefers well-draining soil and can tolerate short periods of drought once established.

Avoid overwatering, which can lead to root rot, especially in cooler conditions. Reduce watering in winter.

Pruning is generally not required unless to remove dead, damaged, or diseased stems. If you wish to shape the plant or encourage bushier growth, light pruning can be done in early spring before new growth emerges.

Remove spent flower stalks to prevent unwanted seeding.

Propagation is typically done by seeds. Sow seeds in spring, either directly outdoors after the last frost or indoors a few weeks prior. Seeds may require stratification or scarification for better germination.

Cuttings are rarely used for this species.

Repotting is rarely necessary as Buffalobur Nightshade is often grown as an annual or a short-lived perennial.

If grown in a container and it becomes root-bound, repot in spring into a slightly larger container with fresh, well-draining potting mix. Ensure adequate drainage holes.