Perennial glasswort thrives in consistently moist soil, mimicking its natural saline or brackish habitats. Water regularly, especially during dry periods, but ensure good drainage to prevent waterlogging.

Avoid letting the soil dry out completely, as this can stress the plant.

Pruning is usually minimal. Remove any dead or damaged stems at any time. Light trimming can be done in late spring or early summer to maintain shape, though it naturally forms a low, spreading habit.

Propagation is easily achieved through stem cuttings taken in spring or early summer. Insert cuttings into moist, well-draining soil or a sand-based medium. They root readily, especially in warm, humid conditions.

Repotting is rarely necessary as Salicornia ambigua is a low-growing, spreading plant. If container-grown and it becomes root-bound, repot in spring to a slightly larger container with well-draining, slightly saline soil.