Water consistently when the top 2-3 cm of soil feels dry. Serjania mexicana prefers moist conditions but dislikes waterlogged roots. Reduce watering in winter to prevent root rot. Ensure good drainage to avoid issues.

In hot climates, more frequent watering may be necessary.

Prune annually in late winter or early spring before new growth begins. Remove any dead, damaged, or crossing branches to maintain shape and promote airflow. This also encourages more vigorous flowering and fruiting.

Light pruning can be done throughout the year as needed.

Propagate from seeds sown in spring, or from stem cuttings taken in late spring or early summer. Seeds may require scarification or a period of cold stratification.

Cuttings should be rooted in a well-draining potting mix and kept moist and warm.

Repot young plants annually or every two years, and mature plants every 3-4 years, in spring. Choose a pot that is slightly larger than the current one. Use a well-draining potting mix.

Repotting helps refresh the soil and provides more space for root growth.