Allow the soil to dry out completely between waterings. Euphorbia nicaeensis is drought-tolerant once established. Overwatering can lead to root rot, so err on the side of caution.

In winter, reduce watering significantly to almost none, especially in cooler climates.

Prune after flowering to maintain shape and encourage bushier growth. Remove any dead or damaged stems at any time. Wear gloves as the sap can be irritating.

Cut back by about a third to half to keep the plant compact and tidy.

Propagate from seed sown in spring or through stem cuttings taken in late spring or early summer. Allow cuttings to callus for a few days before planting in well-draining soil. Seeds may require stratification.

Both methods yield good results.

Repot young plants annually or every two years in spring. Mature plants can be repotted less frequently, only when root-bound. Use a well-draining potting mix, such as a cactus or succulent blend.

Ensure the pot has drainage holes.