Water Tanacetum millefolium regularly during establishment, but allow the soil to dry out slightly between waterings once mature. It is drought-tolerant and prefers well-drained soil, so avoid overwatering, which can lead to root rot.

Prune back spent flower stalks to encourage reblooming and maintain a tidy appearance. In late autumn or early spring, cut the plant back by about half to promote vigorous new growth and prevent it from becoming too woody.

Tanacetum millefolium is easily propagated by division in early spring or autumn. Seeds can also be sown in spring, either directly outdoors or started indoors a few weeks prior.

Cuttings can be taken in late spring or early summer.

Repotting is rarely necessary for Tanacetum millefolium as it is typically grown outdoors in garden beds. If grown in a container, repot every 2-3 years in spring to refresh the soil and provide more space if it becomes root-bound.