Water Trichosanthes scabra thoroughly when the top 2-3 cm of soil feel dry. Avoid waterlogging, especially during dormancy. Reduce watering significantly in cooler months to prevent root rot.

Ensure good drainage to maintain healthy root systems.

Prune to manage size and shape, and to remove any dead or diseased stems. Pruning can be done in late winter or early spring before new growth begins.

For vigorous vines, occasional trimming during the growing season might be necessary.

Propagate Trichosanthes scabra from seeds sown in spring or through stem cuttings taken during the growing season. Seeds may require stratification or scarification. Cuttings should be rooted in a well-draining medium.

Repot young plants annually or bi-annually in spring. Mature plants can be repotted every 2-3 years, or when root-bound.

Use a good quality, well-draining potting mix, and a pot that is only slightly larger than the previous one.