Maintain consistently moist soil during the growing season, especially when fruiting. Water deeply at the base of the plant, avoiding foliage to prevent fungal diseases.

Reduce watering frequency as fruits mature and plants begin to senesce in cooler weather.

Generally, Lagenaria sphaerica requires minimal pruning. Remove any dead, diseased, or damaged stems as they appear.

Pinching back the tips of vines can encourage bushier growth and potentially more fruit production, but this is not strictly necessary.

Seeds are the primary method for propagation. Sow seeds indoors 3-4 weeks before the last expected frost or directly outdoors once temperatures are consistently warm.

Scarify seeds lightly or soak them in warm water for 24 hours to improve germination.

As Lagenaria sphaerica is typically grown as an annual or in open ground, repotting is uncommon. If starting seeds in small pots, transplant them into larger containers or their final garden location once they have developed a few true leaves and are strong enough.