Water moderately during the growing season, allowing the soil to dry out completely between waterings. Reduce watering significantly in winter, providing just enough to prevent complete desiccation.

Overwatering is a common cause of root rot, so ensure good drainage.

Prune in spring after flowering to maintain shape and size. Remove dead, damaged, or crossing branches. Pruning can encourage bushier growth.

For significant size reduction, prune back harder, but be aware that Euphorbia dendroides can be slow to recover from severe pruning.

Propagate from stem cuttings taken in late spring or early summer. Allow cuttings to callus for a few days before planting in well-draining soil mix. Rooting can be slow.

Seed propagation is also possible but less common for home gardeners.

Repot young plants every 2-3 years in spring. Mature plants can be repotted less frequently, perhaps every 4-5 years, or when root-bound. Use a gritty, well-draining potting mix.

Handle with care to avoid damaging the root system and the milky sap.