Water regularly during the growing season, allowing the soil to dry out slightly between waterings. Reduce watering significantly in fall and winter to prevent root rot, as this plant is adapted to arid conditions and prefers well-drained soil.

Pruning is generally not required for this plant. If necessary, trim back any leggy or overgrown stems after flowering to maintain a tidy appearance and encourage bushier growth.

Remove any dead or damaged foliage as needed.

Propagate by seed sown in early spring or late fall. Stratification may improve germination rates. Cuttings can also be taken in spring, but are generally less successful. Ensure good drainage for seedlings.

Repotting is rarely necessary for Cleomella brevipes as it is a small, short-lived perennial or annual. If grown in a container and it becomes root-bound, repot in spring into a slightly larger pot with well-draining soil mix.