Cleomella californica prefers well-drained soil and is drought-tolerant once established. Water moderately during its active growing season, allowing the soil to dry out slightly between waterings.

Reduce watering significantly during dormancy, especially in cooler months, to prevent root rot. Overwatering is a primary cause of failure.

Minimal pruning is required for Cleomella californica. Deadheading spent flowers can encourage further blooming and maintain a tidier appearance.

If the plant becomes leggy or overgrown, light pruning in late winter or early spring before new growth emerges can help maintain its shape. Avoid heavy pruning.

Cleomella californica is best propagated by seeds sown directly outdoors in the fall or early spring, as it dislikes transplanting. Germination is often erratic.

Alternatively, sow seeds indoors several weeks before the last frost, but be cautious when transplanting seedlings, as they have delicate root systems. Do not divide.

Repotting is generally not recommended for Cleomella californica due to its sensitive root system and preference for undisturbed soil.

It is best grown directly in the ground or in a container that will not require frequent repotting. If container-grown, use a well-draining potting mix and consider replacing the top layer of soil.