Water moderately during the growing season, allowing the soil to dry out slightly between waterings. Reduce watering significantly in winter, providing just enough to prevent complete desiccation.

Euclea polyandra is relatively drought-tolerant once established, so avoid overwatering, which can lead to root rot.

Prune to maintain shape and remove any dead or crossing branches. Light pruning can be done after flowering to encourage bushier growth. Avoid heavy pruning, as it can stress the plant.

Removal of suckers may be necessary to control spread if it becomes invasive.

Propagate from seeds sown in spring, which may require scarification or stratification. Cuttings can also be taken from semi-hardwood or hardwood in late summer or autumn.

Ensure cuttings have at least two nodes and are treated with rooting hormone for better success.

Repot young plants annually or biannually in spring as needed. Mature plants can remain in their pots for several years. Use a well-draining potting mix, such as a sandy loam or cactus mix.

Repotting is best done when the plant is not in active growth, typically in late winter or early spring.