Great Burdock prefers consistently moist soil, especially during its active growth phases in spring and summer. Water deeply when the top few centimeters of soil feel dry to the touch. Avoid waterlogging, as this can lead to root rot. Established plants can tolerate short periods of drought, but regular watering promotes healthier growth and larger roots for harvest.

Pruning for Great Burdock primarily involves removing flower stalks in the first year to encourage root development if growing for harvest. In the second year, after flowering and seed set, the entire plant will die back. Removing spent flower heads can prevent excessive self-seeding, which helps manage its spread and weed potential in garden settings.

Great Burdock is primarily propagated by seed. Seeds can be sown directly outdoors in late autumn or early spring. They require light to germinate, so sow them shallowly, barely covering with soil. Ensure consistent moisture during germination. It readily self-seeds, so managing its spread is often more of a concern than active propagation.

As a large, taprooted biennial, Great Burdock is not typically grown in pots or repotted. Its deep root system requires ample space in the ground to develop properly. Attempting to grow it in containers would severely restrict root growth and overall plant size, making it unsuitable for its natural growth habit and for root harvest.